I型干扰素信号传递和过氧体功能障碍有助于增强IRGM1缺陷巨细胞中炎症性细胞因子的产生

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Brian E Fee1, Lanette R Fee1, Mark Menechella1

  • 1Department of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development; Duke University Medical Center, Durham, North Carolina, USA.

The Journal of biological chemistry
|October 12, 2024
PubMed
概括

该IRGM基因调节炎症反应. 它在巨细胞中的缺陷增加了由过氧体失调和I型干扰素生产驱动的炎症性细胞因子,为炎症性疾病提供了新的见解.

关键词:
这是一个GTPase.诱导细胞因子诱导干扰子干扰子干扰子巨细胞是一个巨细胞.过氧组的过氧组.

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