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来自中国云南的五种新型蝙蝠冠状病毒的鉴定和遗传特征

Qian Li^1,2, Yutong Hou¹, Baoyang Huang¹

¹Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, P. R. China.

BMC veterinary research

|October 12, 2024

概括

蝙蝠是各种冠状病毒 (CoV) 的宿主,经常观察到重组事件. 阿尔法冠状病毒具有更高的跨物种传播潜力,而贝塔冠状病毒更具宿主特异性,这凸显了需要持续对蝙蝠进行监测,以防止动物传播的溢出.

科学领域:

病毒学病毒学
基因组学就是基因组学.
动物传播疾病动物传播疾病

背景情况:

冠状病毒 (CoV) 构成重大全球健康威胁,导致传染性和特有传染病.
蝙蝠是各种病毒的天然储存库,包括多个CoV,这引发了对动物感染潜力的担忧.

研究的目的:

研究蝙蝠冠状病毒的多样性和基因组特征.
分析蝙蝠CoV的重组模式和进化动态.
评估蝙蝠CoVs跨物种传播的可能性.

主要方法:

来自云南省的61只蝙蝠的基因组测序.
鉴定和表征七种CoV,包括α和βCoV.
对遗传结构,重组模式和进化关系的分析.

主要成果:

确定了七种CoV,包括三种alpha-CoV (四种Decacovirus,一种Minunacovirus) 和两种β-CoV (Sarbecovirus亚属).
新发现包括独特的ORF模式和一个Minunacovirus亚属Cov (YJ3c/f).
菌株JCC9表现出独特的重组和更高的结合亲和力与/松鼠ACE2受体;菌株HpJC8xc表现出宿主间传播和蝙蝠的重组,表明有动物传播风险.

结论:

蝙蝠CoV表现出高度多样性,并经常进行重组.
阿尔法-CoVs更容易在蝙蝠家族之间进行跨物种传播,而β-CoVs表现出宿主特异性.
持续监测蝙蝠对于预防新型冠状病毒爆发和人类和牲畜中动物性疾病至关重要.

关键词:

蝙蝠蝙蝠蝙蝠蝙蝠在标志性描述标志性描述冠状病毒冠状病毒传输传输传输传输云南云南是一个

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