中间前额叶皮层的谷氨酸度与成行为相反相关:一个转化性研究
Hui Zhou1,2, Tiantian Hong1, Xi Chen3
1Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, 311100, China.
Translational psychiatry
|October 12, 2024
概括
像前皮质 (PrL) 和背前环状皮质 (dACC) 这样的大脑区域的低谷氨酸水平与成有关,包括互联网游戏障碍 (IGD). 增强dACC谷氨酸可能有助于成治疗.
科学领域:
- 神经科学是一个神经科学.
- 成的神经生物学成的神经生物学
- 神经化学 神经化学
背景情况:
- 调节失调的前腹状回路是物质使用障碍和行为成 (如互联网游戏障碍 (IGD)) 中的强迫行为基础.
- 这些成行为的特定神经化学基础在很大程度上是未知的.
- 动物模型的局限性阻碍了对成中神经可塑性的理解.
研究的目的:
- 调查区域谷氨酸 (Glu) 度与成行为之间的关系.
- 结合来自强迫性寻找/服用药物的老鼠模型和不同程度的IGD严重性的人类参与者的数据.
- 探索Glu在成的神经基质中的作用.
主要方法:
- 使用了一种强迫性甲基胺自给药 (SA) 的老鼠模型.
- 使用神经成像技术测量了老鼠前皮层 (PrL) 和人类背前带状皮层 (dACC) 的区域Glu度.
- 对患有IGD的人类参与者进行了全面的认知评估.
- 分析了Glu水平,成行为,自我控制和正念意识之间的相关性.
主要成果:
- 与对照组相比,大鼠在20天的甲基胺SA后在PrL中显示出显著较低的GLU水平.
- 在老鼠中,惩罚后的Glu度与急性寻找药物的行为有负相关性.
- 葡萄糖水平的变化与戒断期间寻找药物的负相关.
- 患有IGD的人类参与者在dACC Glu度和IGD症状严重程度之间表现出负相关性.
- 较高的dACC Glu水平与人类的自我控制和正念意识有积极的相关性.
- dACC Glu度调解了自我控制/正念意识与IGD症状之间的关系.
结论:
- 一致的证据表明,dACC/PrL在成中起着保护作用.
- 这些地区较低的Glu水平与强迫性成行为有关.
- 旨在增强dACC谷氨基胺基功能的干预措施可能是预防和治疗成的潜在策略.
相关概念视频
Drug Abuse and Addiction: Pharmacological Phenomena
447
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
447
Attention-Deficit/Hyperactivity Disorder
47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47
CNS Depressants: Alcohol and Nicotine
178
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
178


