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Updated: Jun 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对C-degron E3 KLHDC2参与的对应物特异性向蛋白质降解的原理2

Daniel C Scott1, Suresh Dharuman2, Elizabeth Griffith2

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Nature communications
|October 12, 2024
PubMed
概括

这项研究介绍了KLHDC2作为一种新型E3结合酶,用于蛋白质溶解向合体 (PROTAC) 技术,可选择性降解BRD3.3等向蛋白质. 这扩大了针对蛋白质降解的PROTAC能力.

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