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与疼痛相关的负面情绪和特征负面情绪对炎症性肠病患者的大脑功能的影响不同
Ling Yang1,2,3, Lingqin Zhang2, Yan Liu4
1Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan Second Road, Yuzhong District, Chongqing, 400000, China.
炎症性肠病 (IBD) 与明显的脑活动变化有关. 前带带皮层 (ACC) 活动与疼痛情绪相关,而左侧中心后环活动与IBD患者的抑郁有关.
科学领域:
- 神经成像是一种神经成像.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 炎症性肠道疾病 (IBD) 是一种经常与负面情绪状态并发的慢性疾病.
- 在IBD患者中,特定的大脑功能与明显的负面情绪之间的关系尚不清楚.
研究的目的:
- 研究IBD患者与疼痛相关和特征负面情绪的独特神经支.
- 探索IBD中改变的大脑活动和情绪维度之间的关联.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估98名IBD患者和46名健康对照者的静止状态大脑活动.
- 分析包括低频波动 (ALFF),区域同质性 (ReHo) 和中心度 (DC) 的幅度.
- 部分最小平方 (PLS) 相关性被应用来将大脑活动与情绪状态联系起来.
主要成果:
- 与对照组相比,IBD患者在右前带状皮质 (ACC) 中显示出更高的ALFF,在双边ACC中显示出更高的DC.
- 在IBD患者的左后中心囊中观察到较低的ALFF.
- ACC大脑得分与与疼痛相关的负面情绪相关,以及与特征抑郁症相关的左后中枢环活动.
结论:
- 在ACC中,大脑活动明显与IBD中与疼痛相关的负面情绪有关.
- 左侧中后回形的活性变化与IBD患者的高阶特征抑郁有关.
- 这些发现澄清了不同负面情绪维度如何影响IBD中的大脑功能.
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