实验室预测器用于诊断大肠解体泄漏
M Gordiichuk1,2, S Myasoyedov1
1Shupyk National University of Healthcare of Ukraine, Kyiv, Ukraine.
Experimental oncology
|October 13, 2024
概括
预测结肠直肠静脉泄漏 (AL) 是至关重要的. 这项研究确定了关键的炎症标志物,如淋巴细胞,血小板和中性粒细胞/淋巴细胞比率,以改善早期AL诊断和治疗.
科学领域:
- 结肠直肠病学 (coloproctology) 是一种大肠直肠病学.
- 在瘤学瘤学.
- 外科胃肠道外科手术
背景情况:
- 结肠直肠静脉泄漏 (AL) 是瘤结肠直肠病学的一个重要并发症,报告的发病率在3.5%至21%之间.
- 早期预测AL对于有效管理和改善患者的治疗结果至关重要.
研究的目的:
- 通过识别实验室标记的组合和值,增强对道泄漏 (AL) 的早期诊断.
- 建立可靠的炎症过程预测因子,以便及时检测AL.
主要方法:
- 一项前性研究涉及213名直肠癌患者,这些患者接受了低前切除后的新辅助化学放射治疗 (2020-2023年).
- 评估炎症生物标志物,包括C反应蛋白 (CRP),前素 (PCT),中性粒细胞 (NEU),淋巴细胞 (LYM),血小板 (PLT) 和中性粒细胞/淋巴细胞比率 (NLR) 在手术前和后.
- 使用LYM,PLT和NLR开发AL的三因素预测模型.
主要成果:
- 在11.74%的患者中,发生了道泄漏 (AL),严重程度为B级和C级,显示炎症标志物的显著变化.
- 淋巴细胞 (LYM),血小板 (PLT) 和中性粒细胞/淋巴细胞比率 (NLR) 被确定为AL在发病前24小时的显著预测因素.
- 结合LYM,PLT和NLR的三因素预测模型显示,预测AL的灵敏度为80%,特异性为74.2%.
结论:
- 常规的实验室标记物,特别是LYM,PLT和NLR,可以用于早期和有效地诊断临床上显著的B或C等级的道性泄漏 (AL).
- 开发的预测模型有助于及时诊断,使得AL的及时药物治疗和手术介入成为可能.
相关概念视频
Assessment of the Rectum and Anus
162
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
162
Serum Laboratory Studies, Stool Test, Breath Test
318
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
318
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
53
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
53
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
56
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
56
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
94
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
94


