基于溶剂二甲基硫氧化物被单一氧气氧化氧化的行为来确定单片氧的量子产量
Meng Kou1, Feng Qin2, Yongda Wang2
1School of Physics, Harbin Institute of Technology, Harbin, 150001, China.
Analytica chimica acta
|October 13, 2024
概括
一种新方法准确地测量了光动力疗法 (PDT) 光敏剂的单个氧量子收益率 (ΦΔ). 这种无探针的方法使用二甲基硫氧化物 (DMSO),提高了PDT研究的准确性和适用性.
科学领域:
- 摄影化学的使用.
- 生物医学工程 生物医学工程
- 分析化学 分析化学
背景情况:
- 光动力疗法 (PDT) 的疗效依赖于单片氧 (1O2) 生成.
- 单一氧量子收益率 (ΦΔ) 量化了PDT效率,但目前的测量方法有限.
- 现有的 ΦΔ 测定方法存在信号-噪声差或严格的激发波长要求.
研究的目的:
- 开发一种直接的,无探针的方法来确定光敏剂的单氧量子产量 (ΦΔ).
- 建立一个可靠和广泛适用的技术,用于 ΦΔ测量在光动力学治疗研究.
- 克服现有方法的局限性,提高准确性和减少潜在干扰.
主要方法:
- 开发了一种使用二甲基硫氧化物 (DMSO) 作为反应剂检测1O2生产的新方法.
- 确定了1O2生成与DMSO吸收光谱的可观测变化之间的相关性.
- 通过在不同条件下测量孟加拉 (RB) 和血甲乙烯 (HMME) 的 ΦΔ 验证了该方法.
主要成果:
- 开发的方法通过监测DMSO氧化到二甲基硫,成功确定了光敏剂的ΦΔ.
- 对RB的ΦΔ的测量显示了不同度和光强度的一致性.
- 通过这种方法获得的HMME的ΦΔ值与已建立的1,3-二利索硫 (DPBF) 捕获探头的值保持一致,证实了可靠性.
结论:
- 引入了一种直接的,无探头的方法来准确地确定 ΦΔ,适用于更广泛的激发波长范围.
- 使用DMSO简化了测量过程,提高了测量精度,减少了光敏剂表征干扰.
- 这一进步促进了对光敏剂特性的进一步研究,并加速了光动力学疗法的发展.
相关概念视频
02:44Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
9.9K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
9.9K
02:37Oxidation of Alcohols
12.8K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
The process of oxidation in a chemical reaction is observed in any of the three forms:
12.8K
01:17Oxidation of Phenols to Quinones
2.9K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
2.9K
01:46Oxidative Cleavage of Alkenes: Ozonolysis
10.0K
In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
10.0K
02:21Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate
11.0K
Alkenes can be dihydroxylated using potassium permanganate. The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
11.0K
02:04Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
5.7K
Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
5.7K