使用甲索特雷克萨特的患者的胃肠道症状:在患有类风湿性关节炎的样本中进行横截面研究
Carina Albuquerque Roberto1, Isabela Stachevski1, Barbara Stadler Kahlow1
1Mackenzie Evangelical School of Medicine, Curitiba, Brazil.
Reumatologia clinica
|October 13, 2024
概括
胃肠道不耐受性影响了超过一半的类风湿性关节炎患者接受甲状腺素治疗,通常与纤维肌痛和某些药物有关. 这种不耐受性会影响对治疗的坚持.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 甲托雷克萨特是一种常见的治疗类风湿性关节炎 (RA).
- 胃肠道 (GI) 不耐受是 RA 患者中甲状腺素治疗的常见副作用.
- 胃肠道不耐症可能导致患者停止关键的RA治疗.
研究的目的:
- 为了确定RA患者的胃肠道症状的患病率,使用甲醇.
- 研究胃肠道症状与临床/流行病学因素之间的关联.
- 评估胃肠道不耐受性对甲状腺素坚持性的影响.
主要方法:
- 一项涉及192名患有胃肠道症状的RA患者的横截面研究.
- 使用甲甲酸不耐受性严重性评分 (MISS) 来量化不耐受性.
- 通过图表审查和患者采访收集临床和流行病学数据.
- 使用莫里斯基-格林-莱文问卷评估了甲状腺素的坚持.
主要成果:
- 观察到甲状腺素不耐受的高患病率,有55.7%的患者被归类为不耐受.
- 恶心和吞后的疼痛是最常见的胃肠道疾病.
- 不耐受性与非裔后裔背景,纤维肌痛和同时使用葡萄糖皮质类药物和JAK抑制剂有显著关联.
- 葡萄糖皮质激素的使用与甲状腺素不耐受 (OR=1.85) 独立相关.
结论:
- 甲索酸不耐受性在RA患者中非常普遍.
- 诸如非洲裔种族,共存的纤维肌痛以及使用葡萄皮质类药物或JAK抑制剂等因素会增加不耐受症的风险.
- 甲托雷克萨特不耐受与适度坚持药物治疗有关.
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