患有严重无症状大脑动脉狭窄症的患者的高甘油三和治疗资格:CREST 2试验
Seemant Chaturvedi1, Tanya N Turan2, Jenifer H Voeks2
1University of Maryland, USA.
概括
高甘油 (TG) 水平常见于无症状大脑动脉狭窄症患者. 高TG与糖尿病,高血压和肥胖有关,因此需要进一步研究治疗效益.
科学领域:
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
- 临床试验 临床试验
背景情况:
- 高水平的甘油三 (TG) 影响大约25%的成年人.
- 在服用他类药物的患者中,药理治疗高TG可能会减少血管事件,但证据是混合的.
- 在无症状大脑动脉狭窄 (CS) 患者中,高TG和相关疾病的患病率尚不清楚.
研究的目的:
- 确定患有无症状动脉狭窄症 (CS) 的患者中TG水平升高的患病率.
- 在这个患者群体中识别与高TG相关的疾病.
- 根据已确定的标准,评估符合TG降低治疗的资格.
主要方法:
- 在CREST 2试验中对2328名患者的基线脂质样本进行分析.
- 使用REDUCE-IT标准评估TG治疗的适用性 (TG≥150 mg/dL,LDL<100 mg/dL在他类药物治疗中).
- 用于评估基线因子和高TG水平之间的关联的Chi-square和t测试.
主要成果:
- 符合REDUCE-IT标准的患者中有20.5%有资格接受TG降低治疗.
- 平均TG水平为205 mg/dL.
- 高TG水平 (≥150 mg/dL) 与高血压,糖尿病,肥胖,高HbA1c和减少体力活动 (p<0.0001) 有显著的关联.
结论:
- 升高的TG水平很普遍,并且与无症状的CS患者常见的并发症密切相关.
- 需要进行进一步的研究,以确定治疗高TG水平是否有利于无症状动脉狭窄症患者.
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