像暴饮暴食的行为代际转移:青少年压力增加的影响
Elin Kachuki Dory1, Avi Gueta2, Yoni Loterstein1
1Department of Psychology, Bar Ilan University, Ramat Gan, Israel; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat-Gan, Israel.
Appetite
|October 13, 2024
概括
小鼠后代的青春期压力加剧了暴饮暴食行为,特别是在那些母亲不经常获得美味食物的小鼠中. 这表明,早期生活压力和母亲因素在暴饮暴食的发展之间存在复杂的相互作用.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 内分泌学 在内分泌学.
背景情况:
- 暴饮暴食 (BE) 是一种复杂的饮食障碍,其特点是大量食用食物而失去控制.
- 遗传因素和早期生活压力,如青少年压力 (JS),与BE的发病和发展有关.
- 了解压力和母亲养模式对代际影响对于阐明BE机制至关重要.
研究的目的:
- 为了研究青少年压力对动物模型中暴饮暴食行为的影响.
- 检查母体可口食物获取频率对后代应激反应和饮食行为的影响.
- 探索母亲的饮食和后代的青少年压力对生理压力标志物的综合影响.
主要方法:
- 雌性Wistar大鼠接受了不同的美味食物获取计划 (每周3次或5次).
- 后代在特定的出生后几天经历了青少年压力 (O-JSC) 或作为对照 (O-CC).
- 进行了行为测试 (开放场地,升高加迷宫,黑暗/光明盒) 和头发皮质醇分析,以评估压力和暴饮暴食倾向.
主要成果:
- 获得母体可口食物的次数较少的老鼠 (每周3次) 呈现出更大的狂饮大小和更高的可口食物消费量.
- 与对照组 (O-CC) 相比,暴露于青少年压力的后代 (O-JSC) 显示出高度焦虑的行为和增加的食物摄入量.
- 母亲每周3次养和后代青春期压力的结合导致头发皮质醇水平升高,表明慢性压力.
结论:
- 母亲的养模式和后代的早期生活压力显著相互作用,影响过度饮食行为和应激反应.
- 青春期的压力加剧了暴饮暴食的倾向,特别是当与母亲的饮食限制相结合时.
- 这项研究提供了关于代际暴饮暴食障碍背后的神经生物学和环境机制的见解.
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