基于宿主基因和微生物群的个性化药物应用于结直肠癌
Adriana González1, Iker Badiola2, Asier Fullaondo1
1Hologenomics Research Group, Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country, Spain.
Advances in genetics
|October 13, 2024
概括
精准医学通过使用生物标志物和肠道微生物群来推进结直肠癌 (CRC) 护理. 个性化策略可以改善CRC的预防,诊断和治疗,最大限度地减少副作用并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 微生物组研究 微生物组研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 疾病的异质性需要个性化医疗来有效预防,诊断和治疗.
- 确定患者特异性生物标志物对于定制CRC疗法和避免不良影响至关重要.
研究的目的:
- 在CRC中全面审查当前和新兴的精准医学生物标志物.
- 讨论宿主遗传和肠道微生物群在CRC治疗方法中的作用.
- 探索调节肠道微生物群的策略,以改善CRC预防和治疗结果.
主要方法:
- 对CRC的诊断,预后和预测生物标志物的文献综述.
- 对宿主遗传学和肠道微生物群对CRC治疗的影响的分析.
- 对CRC的微生物群调节策略 (饮食,抗生素,移植) 的检查.
主要成果:
- 生物标志物 (突变基因,分子概况) 是个性化CRC诊断和治疗的关键.
- 肠道微生物群的组成影响CRC的发展和治疗反应.
- 调节肠道微生物群显示出减轻治疗副作用和改善CRC结果的潜力.
结论:
- 精准医学,整合生物标志物和微生物群的洞察力,为CRC提供了个性化的方法.
- 宿主基因和肠道微生物群是预防和治疗CRC的关键因素.
- 对肠道微生物群的有针对性的调制为增强CRC护理提供了有希望的途径.
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