身体脂肪变化率与糖尿病病风险之间的关联 - 基于ACCORD数据库的后期分析
Shuai Li1, Li Lin2, Xiaoyue Chen2
1Department of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Xiangya Road 87#, Changsha, 410008, China.
BMC public health
|October 13, 2024
概括
身体脂肪的快速变化增加了2型糖尿病患者,特别是肥胖患者的糖尿病病风险. 对于患有糖尿病的肥胖个体,建议逐渐减肥以减轻这种风险.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢疾病 代谢疾病
背景情况:
- 体重控制对于预防糖尿病病至关重要.
- 身体脂肪波动对糖尿病病风险的影响尚不清楚.
- 这项研究探讨了2型糖尿病中体脂变化率与糖尿病病之间的关联.
研究的目的:
- 调查身体脂肪变化率与糖尿病病发病率之间的关系.
- 探索身体质量指数 (BMI) 对这一关联的修改效应.
主要方法:
- 利用了来自"控制糖尿病心血管风险的行动" (ACCORD) 试验的数据.
- 计算了两年内身体脂肪变化率,并将参与者分为低和高组.
- 采用Cox比例危险模型和倾向性得分匹配来估计危险比率和对混因素的控制.
主要成果:
- 较高的体脂变化率与糖尿病病的风险增加有关 (HR 1.13,95% CI 1.01-1.26).
- 观察到身体脂肪变化率和BMI之间的显著相互作用 (P相互作用 = 0.008).
- 增加的风险仅在肥胖参与者 (BMI > 30;HR 1.34,95% CI 1.08-1.66) 中显著.
结论:
- 身体脂肪变化率与2型糖尿病患者糖尿病病的风险更高有关.
- 这种关联在肥胖个体中是显著的,这表明BMI改变了风险.
- 为肥胖糖尿病患者推逐步减肥策略,以防止剧烈的身体脂肪波动并降低病风险.
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