在WISDOM研究中的个性化乳腺癌教育工具后,风险降低活动的验证研究
Tianyi Wang1,2, Mandy Che1,3, Yash S Huilgol4
1UC San Francisco Department of Surgery, San Francisco, CA, USA.
NPJ breast cancer
|October 13, 2024
概括
一个虚拟乳腺健康工具增加了高风险女性采取降低风险活动的意愿. 然而,对副作用的恐惧仍然是一个重要的障碍,特别是在降低内分泌风险方面.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 医疗信息学 医疗信息学
背景情况:
- 有验证的乳腺癌风险降低策略存在,但高风险人群面临采用障碍.
- 了解这些障碍对于改善采取预防措施至关重要.
研究的目的:
- 评估虚拟乳腺健康决策工具对高风险女性风险降低活动采用的影响.
- 确定采用乳腺癌风险降低策略的障碍.
- 评估该工具对乳腺癌焦虑的影响.
主要方法:
- 这项研究涉及318名高风险参与者,他们来自Women Informed to Screen Depending on Measures of Risk (WISDOM) 试验的调查部门.
- 参与者审查了虚拟乳腺健康决策工具,并完成了反调查.
- 在为期三个月的后续调查中,评估了采取风险降低活动的情况.
主要成果:
- 基线采用率:内分泌风险降低4.7%,减少酒精38.7%,运动62.6%.
- 随访显示,与内分泌风险降低 (13.1%) 相比,考虑后减少酒精 (68%) 和运动 (58%) 的追求率更高.
- 害怕副作用是减少内分泌风险的主要障碍.
结论:
- 虚拟工具显示了鼓励改变生活方式以减少乳腺癌风险的潜力.
- 显著的障碍,特别是对副作用的恐惧,阻碍了内分泌风险降低的采用.
- 需要对决策工具进行进一步改进,以提高其有效性.
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
123
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
123
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Hazard Ratio
91
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
91
Comparing the Survival Analysis of Two or More Groups
156
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
156
Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


