早期母乳养:与肠道屏障成熟和产后生长的关系
Lisa Roskes1, Athanasios Chamzas2, Bing Ma3
1Department of Pediatrics, University of Maryland School of Medicine, 22 S, Greene St, Baltimore, Maryland, 21201, USA.
Pediatric research
|October 13, 2024
概括
早产婴儿的早期肠壁成熟与在10天内消费超过150毫升/千克的母乳 (MOM) 或捐赠人乳 (DHM) 有关. 这种摄入促进了肠道健康,但并不能防止产后生长失败.
科学领域:
- 新生儿营养新生儿营养
- 胃肠病学 胃肠病学
- 儿科研究的研究.
背景情况:
- 早期接触母乳 (MOM) 对早产婴儿的肠道屏障成熟至关重要.
- 当MOM无法使用时,捐赠人乳 (DHM) 是另一种选择.
- 补充DHM对早产婴儿肠道透性 (IP) 和生长的影响需要进一步调查.
研究的目的:
- 调查捐赠人母乳 (DHM) 补充剂是否会降低肠道透性 (IP),类似于纯母乳 (MOM).
- 为了确定早期人乳 (HM) 暴露和低IP是否与早产婴儿的改善生长结果有关.
主要方法:
- 使用标准糖吸收测试 (SAT) 评估了肠道透性 (IP) 在7-10天产后年龄 (PNA) 之间的早产婴儿 (<33周妊娠) 中.
- 收集了营养和人类学数据.
- 产后生长衰竭 (PNGF) 被定义为从出生到出院的体重z-score下降>1.
主要成果:
- 接受独家MOM或DHM±MOM的婴儿与接受早产婴儿配方±MOM的婴儿相比,IP显著较低.
- 7-10天内MOM±DHM的累计摄入量>150毫升/公斤PNA与早期肠道屏障成熟有关.
- 低IP与在出院时产后生长衰竭 (PNGF) 的风险降低无关.
结论:
- 在早产婴儿的早期肠道屏障成熟与在生命的前10天内单独服用或补充DHM的累计摄入量>150毫升/公斤的MOM有关.
- 补充DHM促进肠道屏障成熟,与单独的MOM相比.
- 虽然对肠道健康至关重要,但早期人体牛奶摄入量与出生后生长不良的发病率较低无关.
相关概念视频
Anatomy of the Intestines
71.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.5K
Development of Immunocompetence
293
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
293
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Parental Care
11.6K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
11.6K


