糖化血红蛋白与早期心脏衰老的多模式成像标志物之间的关联
Abigail C C Chng1, Hong Chang Tan2,3, Louis L Y Teo1,2
1National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
GeroScience
|October 13, 2024
概括
糖化血红蛋白 (HbA1c) 可以预测心肌衰老在没有糖尿病的老年人. 较高的HbA1c水平与心脏功能的改变有关,这表明它可以用于评估心血管风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 糖化血红蛋白 (HbA1c) 是糖尿病管理和心血管死亡风险的关键生物标志物.
- 在没有心血管疾病 (CVD) 的非糖尿病成年人中预测心肌衰老的作用仍然未被探索.
研究的目的:
- 在没有心脏病或糖尿病的老年人中研究HbA1c和心肌衰老标志物之间的联系.
- 为了确定HbA1c是否可以预测肌肉心脏衰老的不同特征.
主要方法:
- 在没有心血管疾病的老年人中进行全面的心血管和代谢评估.
- 心声和心磁共振 (CMR) 用于左心室和左心房 (LA) 应变分析.
- 取血样检测HbA1c和其他生物标志物.
主要成果:
- HbA1c与E/A比率,LA导管应变 (Ɛe),导管应变率 (SRe) 和SRe:SRa比率显著相关.
- 这些关联在调整临床因素并排除糖尿病患者后独立地持续存在.
- 增加的HbA1c与较低的E/A比率,较低的Ee,较高的SRe和较低的SRe:SRa比率相关.
结论:
- HbA1c与心肌功能有着明显的关联,这与心脏衰老有关.
- HbA1c可以作为一种有价值的生物标志物,用于风险分层在心肌衰老,无论糖尿病状态.
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