身体组成与心脏结构和功能之间的关系中的性别差异.
Heidi S Hartman1, Eunyoung Kim1, Salvatore Carbone2
1Division of Cardiology, Columbia University Irving Medical Center, 630 W 168th St, New York, NY 10032, USA.
European heart journal. Cardiovascular Imaging
|October 14, 2024
概括
内脏脂肪组织和肌肉脂肪透与女性心脏质量增加有关,但男性并非如此. 瘦身量对两性人的心脏大小都有影响. 胰岛素抵抗可能会调解与脂肪有关的心脏变化.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物医学工程 生物医学工程
背景情况:
- 身体成分显著影响心血管健康.
- 越来越多地认识到身体组成和心脏参数的性别特异性差异.
- 了解这些性别差异对于有针对性的心血管疾病预防和治疗至关重要.
研究的目的:
- 研究身体组成指标与心脏结构/功能之间的关系中的性别差异.
- 探索潜在的病理生理学媒介,如胰岛素抵抗,将身体组成与心脏参数联系起来.
主要方法:
- 对25 063名英国生物库参与者的横截面分析.
- 线性回归模型用于评估内脏脂肪组织体积 (VAT),尾瘦质量 (ALM) 和肌肉脂肪透 (MFI) 与心磁共振 (CMR) 测量之间的关联.
- 因果调解分析以确定调解脂肪储存与心脏参数之间的关系的生物标志物.
主要成果:
- 内脏脂肪组织 (VAT) 与女性左心室质量 (LVM) 和壁厚度的增加有关,但男性没有.
- 肌肉脂肪透 (MFI) 显示与LVM具有相似的性别特异性关联,仅在女性中显著.
- 尾肌瘦质量 (ALM) 与两性中增加的LVM和左心室体积有关.
- 胰岛素耐药性 (甘油三和高密度脂蛋白比率) 部分介导了增值税对心室尺寸的影响.
结论:
- 内脏脂肪组织 (VAT) 和肌肉脂肪透 (MFI) 与女性的不良心脏重塑 (增加LVM,壁厚) 有关,但男性没有.
- 尾肌瘦质量 (ALM) 在两性中都显示出与心脏结构的积极关联.
- 这些发现突出了身体组成如何影响心脏的显著性别差异,这对心血管风险评估和管理有影响.
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