对切除性结直肠癌的术后预后进行比较,使用倾向得分匹配分析与没有瘤紧急情况进行比较:单中心回顾性观察性研究
Ken Imaizumi1, Hiroyuki Kasajima1, Kentaro Sato1
1Department of Gastroenterological Surgery, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan.
Oncology letters
|October 14, 2024
概括
与非紧急病例相比,结肠直肠癌瘤紧急情况会使患者的预后恶化. 辅助化疗显著改善了急诊患者的无复发生存率,这需要深入考虑.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道手术 胃肠道手术
背景情况:
- 结直肠癌 (CRC) 的瘤紧急情况带来了独特的挑战,其长期结果尚不清楚.
- 现有的文献对经历瘤紧急情况的CRC患者的预后提出了相互矛盾的证据.
研究的目的:
- 为了比较CRC患者与没有瘤紧急情况之间的术后预后.
- 分析基于紧急情况类型 (阻塞与穿孔) 和复发模式的预后.
- 评估辅助化疗对紧急病例无复发存活率的影响.
主要方法:
- 对524名II/III期CRC患者进行了彻底手术的回顾性分析 (2012-2020年).
- 将其分为非紧急和瘤紧急组 (阻塞/穿孔).
- 用于结果比较的倾向性得分匹配.
主要成果:
- 与非紧急病例相比,瘤紧急情况与术后预后更差有关.
- 阻塞和穿孔子组的预后没有显著差异.
- 腹膜传播在阻塞中更频繁,在穿孔中局部复发.
- 辅助化疗改善了瘤急诊患者的无复发生存率.
结论:
- 结直肠癌瘤紧急情况与更差的预后有关,尽管阻塞和穿孔结果可能相似.
- 辅助化疗在改善这些关键病例的无复发生存率方面具有显著的益处.
- 强烈建议在结直肠癌瘤紧急情况的患者中考虑辅助化疗.
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