药物使用和药物坚持治疗牛皮关节炎:一项意大利研究
Fiorenzo Santoleri1, Paolo Abrate2, Laura Pestrin3
1Pescara General Hospital, Pescara - Italy.
Global & regional health technology assessment
|October 14, 2024
概括
生物和向合成修饰疾病的抗风湿药物 (b/tsDMARDs) 在牛皮关节炎 (PsA) 中表现出可变的持久性. 与原始药物相比,生物类药物,特别是乙素,表现出更好的坚持性和显著的成本节省.
科学领域:
- 类风湿病学 类风湿病学
- 药物经济学 药物经济学
- 药物开发 药物开发
背景情况:
- 牛皮关节炎 (PsA) 管理涉及生物和向合成修饰疾病的抗风湿药物 (b/tsDMARDs).
- 治疗的持续性和坚持性对于PsA的最佳临床结果至关重要.
- 了解药物成本和生物类似药的作用对于医疗保健资源优化至关重要.
研究的目的:
- 评估b/tsDMARDs在意大利的PsA患者的持续性,治疗坚持性和药物成本.
- 为了比较原始药和生物类似药的实际有效性和成本效益.
- 评估生物类似药物使用对医疗保健支出的影响.
主要方法:
- 意大利八家医院药房的回顾性观察研究 (2017年1月 - 2020年12月).
- 包括生物/向合成的先前没有使用DMARD的PsA患者,12个月的随访.
- 使用覆盖日数比例 (PDC) 评估持久性和坚持性;原始剂与生物类似的阿达利穆马布和埃坦塞普特的比较.
主要成果:
- 整体1年持久率为48.6%;47.6%的患者坚持 (PDC≥0.8).
- 阿达利穆马布原始剂和生物类似剂显示出类似的持久性和粘附性.
- 与其原始物相比,etanercept生物类似物表现出更好的持久性和坚持性,可节省大量成本 (>每年每患者2,500欧元).
结论:
- 药物坚持不良会对PsA的临床结果产生负面影响.
- 生物相似的乙坦塞普特提供了比原始药物更好的持久性和粘附性.
- 使用生物类似药物支持医疗保健资源优化和PSA管理的成本效益.
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