在胃癌中使用新的免疫治疗方法
Meng Yang1,2, Wuhao Lin3, Jiaqian Huang1,2
1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Precision clinical medicine
|October 14, 2024
概括
胃癌免疫疗法,包括免疫检查点抑制剂和采用细胞疗法,在晚期癌症中显示出有前途. 纳米颗粒可以增强这些新的治疗方法,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
背景情况:
- 胃癌是全球癌症死亡的主要原因,使用传统疗法治疗晚期癌症的结果不佳.
- 免疫疗法提供了一种新的策略,通过向分子多样化的胃癌中的瘤微环境.
- 免疫检查点抑制剂和采用细胞疗法是关键的免疫治疗方法.
研究的目的:
- 审查免疫检查点抑制剂和胃癌的采用细胞疗法的最新进展.
- 讨论当前免疫疗法的局限性以及纳米颗粒在提高治疗疗效方面的潜力.
- 突出胃癌免疫疗法的有希望的目标和临床前研究.
主要方法:
- 关于免疫检查点抑制剂 (例如,布罗利祖马布) 和胃癌中采用细胞治疗的当前文献的综述.
- 对针对claudin的仿真抗原受体-T细胞治疗的临床前数据的分析18.2.2.
- 探索纳米颗粒在调节瘤微环境和改善免疫治疗的作用.
主要成果:
- 编程死亡受体抑制剂与化疗相结合是FDA批准的,并改善胃癌的存活率.
- 采用细胞疗法,特别是针对claudin18.2的仿真抗原受体-T细胞疗法,在临床前模型中显示出抗瘤活性和安全性.
- 纳米颗粒显示出增强免疫疗法传递和疗效的潜力.
结论:
- 免疫疗法,特别是免疫检查点抑制剂和CAR-T细胞疗法,代表了胃癌治疗的重大进展.
- 需要进一步的研究来将临床前发现转化为胃癌免疫治疗的有效临床应用.
- 纳米技术为克服目前固体瘤免疫疗法的局限性提供了一个有希望的途径.
更多相关视频
06:21Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
630
08:59Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
Published on: December 11, 2017
7.2K
相关概念视频
01:27Tumor Immunotherapy
488
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
488
01:30Cancer Vaccines
342
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
342
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
151
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
151
01:26Peptic Ulcer Disease IV: Management
74
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
74