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一种以维生素C为基础的天然深度溶解剂,用于合成2,3-二基纳-4(1H) -one衍生物

Rahman Hosseinzadeh¹, Shiva Zarei¹, Zohreh Valipour¹

¹Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

|October 14, 2024

概括

通过使用胆化物/甲酸深溶剂 (NADES) 实现了2,3-二基纳-4(1H) -one衍生物的绿色合成. 这种环保方法为可持续化学合成提供了高产量和出色的可重复使用性.

科学领域:

绿色化学绿色化学
有机合成有机合成
超分子化学超分子化学

背景情况:

传统的2,3-二基纳-4 (H) - 1衍生物的合成通常涉及恶劣的条件和有毒的溶剂.
在有机化学中,对可持续和环保的合成协议的需求越来越大.

研究的目的:

开发一个有效和绿色的合成路径,用于2,3-dihydroquinazolin-4(1H) -one衍生物.
为了利用天然的深溶性溶剂 (NADES) 作为可持续的反应介质.
评估NADES系统的可回收性和可重复使用性.

主要方法:

制备一种胆化物/亚酸 (ChCl/AA) NADES.
2,3-二基纳-4(1H) -one衍生物通过化物与2-aminobenzamide的凝结进行合成.
在无溶剂条件下使用ChCl/AA NADES合成三组分合成,包括化物,异酸无水化物和盐.
评估该方法的范围与各种芳香,异环和亚利法性化物.

主要成果:

在短的反应时间内获得了2,3-dihydroquinazolin-4(1H) -one衍生物的高产量 (85-97%).
在多个反应周期中,ChCl/AA NADES表现出极好的可回收性和可重复使用性.
该协议证明对多种类型的化物基质有效.

结论:

开发的协议提供了一种高效,绿色和可持续的方法来合成2,3-dihydroquinazolin-4(1H) -one衍生物.
由于其低毒性,生物相容性和成本效益,使用ChCl/AA NADES作为反应介质是有利的.
这种方法符合绿色化学的原则,并为传统合成方法提供了可行的替代方案.

关键词:

绿色化学是一种绿色化学.天然的深层欧特克溶剂溶剂.有机合成有机合成基纳索利诺基的使用方法三个组成部分的反应反应.

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