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血水平与冠状动脉疾病患者的不良结果之间的关联:元分析

Luyu Zhu¹, Ziyan Liu², Shiqi Zhang¹

¹Department of Gastroenterology, The Suqian Clinical College of Xuzhou Medical University, Suqian, Jiangsu, China, 223800.

|October 14, 2024

概括

高血水平 (高血) 显著增加冠状动脉疾病 (CAD) 患者的死亡风险. 在这组患者中,低水平 (低血) 与不良结果没有显著的关联.

科学领域:

心脏病学心脏病学
临床生物化学临床生物化学
流行病学流行病学

背景情况:

冠状动脉疾病 (CAD) 患者血清水平的预后意义尚未得到充分确立.
现有研究提出了关于含量与CAD患者不良结果之间的关联的相互矛盾的发现.

研究的目的:

在被诊断为冠状动脉疾病 (CAD) 的患者中进行元分析,评估血水平的预后作用.

主要方法:

在PubMed,Web of Science,Scopus和Embase数据库中进行了系统的文献搜索,直到2023年12月.
包括的研究是纵向观察性研究 (前性或后性),检查CAD患者的血水平和结果.
结果措施包括全因死亡率,心血管死亡率,心力衰竭,中风和主要心脏不良事件 (MACE). 计算了 95% 置信区间 (CI) 的聚合危险比率 (HR).

主要成果:

分析了6项涉及19553名CAD患者的研究.
高酸血与所有原因死亡率 (HR 1.39; 95% CI 1.20-1.61),心血管死亡率 (HR 1.37; 95% CI 1.22-1.53),心力衰竭 (HR 1.64; 95% CI 1.44-1.87) 和MACEs (HR 1.39; 95% CI 1.03-1.88) 的风险增加显著相关.
在低酸血症和任何研究结果之间没有发现显著的关联.

结论:

超血是不良结果的独立预测因素,包括冠状动脉疾病 (CAD) 患者的死亡率和心力衰竭.
低酸血症似乎不是CAD患者不良事件的显著预后因素.

关键词:

血液中的含量冠状动脉疾病是一种冠状动脉疾病.心脏衰竭是因为心脏衰竭.进行元分析分析.死亡率死亡率死亡率一次性中风,中风.

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