通过高维二进制类不平衡基因表达数据的强有力的加权得分来选择特征
Zardad Khan1, Amjad Ali1, Saeed Aldahmani1
1Department of Statistics and Business Analytics, United Arab Emirates University, Al Ain, United Arab Emirates.
Heliyon
|October 14, 2024
概括
一种新的特征选择方法,不平衡数据的强有力的加权得分 (ROWSU),有效地识别了不平衡基因表达数据中的关键基因. ROWSU通过选择歧视性特征来提高分类准确性,即使在偏分布中也是如此.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 机器学习在基因组学中的应用
背景情况:
- 高维基因表达数据往往会带来阶级不平衡的挑战.
- 偏斜的类分布会对分类算法的性能产生负面影响.
- 有效的特征选择对于基因组学中准确的二进制分类至关重要.
研究的目的:
- 为特征选择提出不平衡数据 (ROWSU) 的强有力的加权得分.
- 为了应对高维基基因表达数据集中的阶级不平衡的挑战.
- 提高对不平衡的基因组数据的分类算法的性能.
主要方法:
- 通过合成少数人过量采样技术进行数据平衡.
- 对于初始最小基因子集选择的贪搜索方法.
- 使用支持矢量权重进行基因改进的新型加权稳健得分.
主要成果:
- ROWSU方法成功地从不平衡的数据集中选择了歧视性基因.
- 在7个基因表达数据集上进行评估,ROWSU表现出卓越的性能.
- 在使用kNN和RF分类器的分类准确度,灵敏度和F1得分方面超越了现有的方法.
结论:
- 拟议的ROWSU方法在不平衡的基因表达数据中的特征选择中是有效的.
- 通过选择最具歧视性的基因,ROWSU提高了分类器的性能.
- 这种方法为基因组学中的二进制分类问题提供了强大的解决方案,其中包含了偏斜数据.
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