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作为布里加替尼的输送系统的Soluplus-TPGS混合:特征和体外评估

Raisuddin Ali1, Wajhul Qamar2, Mohd Abul Kalam1

  • 1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

ACS omega
|October 14, 2024
PubMed
概括

研究人员开发了一种新的Soluplus-TPGS混合菌根系统,以改善Brigatinib (BGT) 对非小细胞肺癌 (NSCLC) 的治疗. 这个系统增强了BGT.

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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