美国成年人心血管健康和低甲状腺功能之间的关联:基于人口的研究
Xiaoxiao Fang1,2, Rui Hu3, Shani Fei2
1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in endocrinology
|October 14, 2024
概括
生命必需8 (LE8) 心血管健康指标的得分较高与甲状腺功能低下的可能性较低有关. 优化心血管健康可能有助于减少甲状腺功能障碍和相关疾病.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 在正常甲状腺激素水平下,甲状腺刺激激素 (TSH) 的升高可能会对心血管健康 (CVH) 产生负面影响.
- 这项研究调查了修订后的Life's Essential 8 (LE8) 心血管健康评估与美国成年人甲状腺功能低下之间的关联.
研究的目的:
- 检查生活必需品8 (LE8) 评分与低甲状腺功能的患病率之间的关系.
- 为了确定心血管健康指标的改善是否与甲状腺功能低下的风险降低有关.
主要方法:
- 利用了2007-2012年国家健康和营养检查调查 (NHANES) 的数据.
- 定义低甲状腺功能为低正常甲状腺功能或亚临床甲状腺功能低下 (SCH).
- 采用多变量逻辑回归来分析LE8得分与低甲状腺功能之间的关联.
主要成果:
- 在6,315名参与者中,21.77%的人甲状腺功能低下.
- 较高的LE8得分与甲状腺功能低下的可能性较低显著相关 (每增加10个点的OR:0.923).
- 身体活动,BMI,血脂,血糖和血压得分的改善与降低的低甲状腺功能率相关.
结论:
- LE8和健康因子评分显示,与低甲状腺功能的患病率有非线性,负面的关系.
- 促进最佳的心血管健康可以减轻低甲状腺功能和心血管疾病 (CVD) 的负担.
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