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在血液透析后患有慢性病的患者中,认知障碍和身体组成指标之间的相关性
Dan Yuan1, Zhenxing Sun2, Jingjing Zhou1
1Department of Nephrology, Beijing Luhe Hospital, Capital Medical University 82 Xinhua South Road, Tongzhou District, Beijing 101100, China.
American journal of translational research
|October 14, 2024
概括
认知障碍影响50%的血液透析患者. 总体体液 (TBW) 和特定液体比率等关键指标与认知能力下降有关,有助于在慢性病 (CKD) 中早期发现.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 认知障碍是慢性病 (CKD) 患者的常见并发症.
- 血液透析是对末期病的治疗方法,可能会影响认知功能.
- 了解与认知障碍相关的因素对于患者管理至关重要.
研究的目的:
- 为了研究体质成分指标和经过血液透析的CKD患者的认知障碍之间的联系.
- 为了确定特定的身体组成参数,可以预测血液透析后的认知障碍.
主要方法:
- 一项对110名慢性病患者进行血液透析后的回顾性研究.
- 在有或没有认知障碍的患者之间比较临床数据和身体组成指标.
- 应用多重物流回归和ROC曲线分析用于风险因素识别和预测模型开发.
主要成果:
- 在50%的研究人口中存在认知障碍.
- 在体质指数 (BMI),瘦身量指数 (LTI),脂肪组织指数 (FTI) 和总体水分 (TBW) 中观察到显著差异.
- 总体水 (TBW),TBW/细胞外水 (ECW) 比率,以及ECW/体细胞质量 (BCM) 比率被确定为认知障碍的独立风险因素.
结论:
- 总体水分 (TBW),TBW/ECW比率和ECW/BCM比率与血液透析后的CKD患者的认知障碍显著相关.
- 身体组成分析是预测这种患者群体认知障碍的一个有价值的工具.
- 这些发现可以指导临床评估和干预策略对慢性病患者的认知健康.
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