松性多草药糊对于洛佩拉胺诱导的老鼠便秘的作用
Imtiaz Gull1, Imran Ahmad Khan2, Abdul Malik3
1Fatima-Tu Zahra Department of Life Sciences, Muhammad Institute of Medical and Allied Sciences Multan 60000, Punjab, Pakistan.
American journal of translational research
|October 14, 2024
概括
这项研究研究了一种多草药糊 (PHP) 用于治疗小鼠的洛佩拉胺诱导的便秘. PHP在便输出和胃肠道运输中表现出显著的改善,表明了治疗潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 自然产品研究自然产品研究
背景情况:
- 洛佩拉胺引起的便秘是一种常见的副作用,需要有效的治疗.
- 多草药配方由于协同作用,提供了潜在的治疗益处.
研究的目的:
- 评估含有蜂蜜中的Rosadamascena,Terminalia chebula和Trachyspermumammi的多草本糊剂 (PHP) 在老鼠模型中对洛佩拉胺诱导的便秘的疗效.
- 评估PHP对与便秘相关的各种生理和组织学参数的影响.
主要方法:
- 三十只雄性大鼠被分为六组,包括对照组,洛佩拉胺诱导的便秘模型和不同剂量 (20,40,60毫克/公斤) 的PHP治疗组.
- 评估的关键参数包括食物和水的消耗,体重,便特征,胃肠道过渡率和组织学变化.
- 还分析了水素-3 (AQP3) 和C-kit的血清生物标志物和蛋白质表达水平.
主要成果:
- 60毫克/公斤的PHP剂量显著增加了便中的水含量 (16.89%),便量 (12.14%) 和胃肠道过渡率 (23.67%),同时减少了黑的时间.
- 40 mg/kg的PHP调节了胃肠道激素水平,增加了莫提林,胃素和物质P,并降低了体静止素.
- 在60 mg/kg的剂量下,PHP减少了结肠损伤,降低了AQP3蛋白表达 (33.39%),并增加了c-kit蛋白表达 (12.14%).
结论:
- 多草药糊 (PHP) 对小鼠的洛佩拉胺诱导的便秘表现出有希望的治疗效果.
- PHP的机制可能包括增强肠道运动性,改善水的吸收,调节与胃肠功能相关的蛋白质表达.
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