安卓素缺乏治疗对前列腺癌老年男性认知功能的影响
Nourhan M Bassyouny1, Mohamed M Gouda1, Mai M Ezz El Din2
1Geriatrics, Faculty of Medicine, Ain Shams University Hospitals, Cairo, EGY.
Cureus
|October 14, 2024
概括
治疗前列腺癌的雄激素剥夺疗法可能会加速认知衰老,并增加老年男性的痴呆风险. 六个月的治疗显示,超过一半的参与者出现轻度认知障碍,影响视觉空间,语言和注意力领域.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 神经科学是一个神经科学.
背景情况:
- 前列腺癌是影响全球数百万男性的一种普遍疾病.
- 雄激素剥夺疗法 (ADT) 是老年前列腺癌患者的主要治疗方法,旨在通过降低水平来抑制疾病的进展.
- ADT可能会导致显著的副作用,包括潜在的认知衰退和加速的认知衰老,可能会增加痴呆风险.
研究的目的:
- 为了评估安素缺乏治疗对最近被诊断为前列腺癌的老年男性认知功能的影响.
- 评估在ADT治疗期间认知领域的变化和抑郁症的发生率.
- 在这个患者群体中调查ADT,认知功能和抑郁症之间的关系.
主要方法:
- 一项前性队列研究涉及85名最近被诊断患有前列腺癌的老年男性,在诊断后两周内开始ADT.
- 通过蒙特利尔认知评估测试 (MoCA) 和MoCA-Basic评估认知功能,通过患者健康问卷-9 (PHQ-9) 评估抑郁症.
- 评估是在治疗开始后的基线,两个月和六个月进行的,不包括先前存在认知障碍或抑郁症的患者.
主要成果:
- 经过六个月的ADT,57.6%的参与者 (85人中49人) 呈现出较低的MoCA分数,表明轻度认知障碍.
- 受影响的特定认知领域包括视觉空间功能,语言和注意力.
- 大约三分之一的参与者在ADT六个月后患有抑郁症,所有抑郁症患者也表现出认知障碍.
结论:
- 雄激素剥夺治疗与关键认知领域 (视觉空间,语言,注意力) 的认知衰退和回归的风险有关,并且在治疗六个月后,在新诊断的前列腺癌的老年男性中增加了抑郁症.
- 虽然抑郁症与认知障碍一起观察到,但在这项研究中无法确定抑郁症和认知衰退之间的直接因果关系.
- 进一步的研究是必不可少的,以探索ADT和认知衰退之间的复杂关系,并制定减轻这些影响的策略,确保整体的患者护理,解决认知和心理健康问题.
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