特兰克萨姆酸的使用是否会增加血栓栓塞的风险?
Ibrahim Al Babtain1,2, Khalid H Alhadlaq3, Ziad A Aljaafri3
1General Surgery, Ministry of National Guard Health Affairs (MNGHA), Riyadh, SAU.
Cureus
|October 14, 2024
概括
这项研究发现,在创伤患者中,酸 (TXA) 和静脉血栓栓塞 (VTE) 风险之间没有显著的联系. 需要进一步的研究来证实对TXA的这些发现.
科学领域:
- 创伤护理 创伤护理
- 药理学 药理学是指药理学的学科.
- 血栓形成的研究研究
背景情况:
- 创伤后的出血是全球主要的死亡原因.
- 静脉血栓塞栓症 (VTE) 是高凝血状态的常见并发症.
- 目前还在讨论TXA与静脉瘤风险之间的关联.
研究的目的:
- 为了研究TXA的管理和创伤患者的静脉瘤发育之间的潜在关联.
- 为了澄清抗纤维解药疗法与血栓事件之间的有争议的联系.
主要方法:
- 对361名接受TXA的成年创伤患者进行了回顾性队列研究.
- 在2016-2020年期间从阿卜杜拉齐兹国王医疗城 (KAMC) 收集的数据.
- 在TXA给药后对VTE (DVT或PE) 和死亡结果的评估.
主要成果:
- 9名患者 (2.5%) 患有深静脉血栓症 (DVT),其中1人死亡.
- 五名患者 (1.4%) 患有肺栓塞 (PE),没有相关死亡.
- 在TXA和VTE风险之间没有发现统计学意义上的关联.
结论:
- 在创伤患者中,与TXA相关的VTE风险仍然没有确定性.
- 这项研究没有证明TXA和VTE之间存在显著联系.
- 需要进行更大规模的研究,以最终确定在创伤中使用TXA后VTE的风险因素.
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