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作为自闭症谱系障碍严重性生物标志物的同核素

Lal D V Nair¹, Senthil Kumar Sivanesan², Devika S Kumar²

¹Pediatrics, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

|October 14, 2024

概括

患有自闭症谱系障碍 (ASD) 的儿童的α-synuclein水平降低与疾病严重程度相关,可能作为生物标志物. 这一发现有助于诊断和评估ASD严重程度,特别是在较轻微的病例中.

科学领域:

神经科学是一个神经科学.
生物化学生化学
发育儿科发育儿科

背景情况:

自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,经过临床诊断.
缺乏用于ASD诊断和严重程度评估的生物标志物.
协核素,特别是α-和β-协核素,与神经退行过程有关,它们在ASD中的作用正在研究中.

研究的目的:

评估被诊断患有ASD的儿童的α-synuclein和β-synuclein的血水平.
与核心自闭症症状的严重程度相关联的同核素水平及其比例.
评估同核素作为自闭症严重程度的生物标志物的潜力.

主要方法:

使用ELISA分析了160名患有自闭症儿童 (2-8岁) 和40名健康对照者的血样本.
使用儿童自闭症评级尺度-2 (CARS-2 ST) 和印度自闭症评估尺度 (ISAA) 评估症状严重程度.
进行了统计分析,包括相关性和接收器操作特征 (ROC) 曲线分析,以确定诊断和严重性预测值.

主要成果:

与对照组相比,ASD儿童的α-synuclein水平明显较低 (p < 0.001).与对照组相比,ASD儿童的α-synuclein水平明显较低 (p < 0.001).
在ASD中,β-同核素水平升高,但与对照人群没有显著差异.
降低的α-synuclein水平与ASD严重程度有显著的相关性,显示出86%的诊断准确性和良好的敏感性和特异性来区分严重程度.

结论:

阿尔法和β-synuclein与ASD相关,阿尔法-synuclein水平与疾病严重程度相关.
阿尔法同核素的折叠下降显示为评估ASD严重性的生物标志物具有前途,特别是在区分轻度和高功能自闭症方面.
进一步的研究可能会验证同核素作为ASD诊断和管理的客观工具.

关键词:

这是一种α-synuclein.自闭症生物标志物自闭症生物标志物自闭症谱系障碍 (ASD) 是一种这是一种β-synuclein.儿童自闭症率尺度儿童自闭症率尺度循环生物标志物循环生物标志物血清生物标志物的血清生物标志物

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