在海湾战争病患者退伍军人中出现小纤维神经病变
Edward C Shadiack1,2, Omowunmi Osinubi1,2, Apollonia Gruber-Fox2
1Veterans Affairs New Jersey Health Care Systems, East Orange.
概括
小纤维神经病变 (SFN) 在海湾战争疾病 (GWI) 退伍军人中很常见,在大多数情况下都有确定的原因. 部署暴露可能导致异常性SFN,但SFN不能完全解释GWI症状.
科学领域:
- 神经学 神经学
- 军事医学 军事医学
- 毒理学 毒理学 毒理学
背景情况:
- 海湾战争疾病 (GWI) 在行动"沙漠盾牌"和"沙漠风暴"的退伍军人中呈现慢性多系统性症状.
- 自主神经系统 (ANS) 功能障碍在GWI中经常被报告,这表明潜在的病理生理学联系.
- 小纤维神经病变 (SFN) 与GWI有类似的症状,并与有毒暴露有关.
研究的目的:
- 确定在被诊断为GWI的退伍军人中活检确认的SFN的患病率.
- 为了比较GWI退伍军人与没有SFN之间的ANS功能障碍症状的负担.
- 在GWI退伍军人中确定SFN的潜在病因.
主要方法:
- 在新泽西州的战争相关疾病和伤害研究中心对海湾战争退伍军人的临床数据进行了回顾性图表审查.
- 分析皮肤活检结果以确认SFN诊断.
- 从医疗记录中抽象GWI状态,SFN诊断和ANS症状负担.
主要成果:
- 在接受皮肤活检的51名海湾战争退伍军人中,42人 (83%) 患有GWI,其中24人 (57%) 也患有SFN.
- 在GWI退伍军人与没有SFN之间,在ANS症状中没有发现显著的差异.
- 在67%的患有SFN的GWI退伍军人中发现了SFN的潜在病因,包括高脂血症,这一比例上升到79%.
结论:
- 小纤维神经病变 (SFN) 在这一群海湾战争疾病 (GWI) 退伍军人中很普遍.
- 虽然在大多数情况下发现了SFN的潜在原因,但大约20%的GWI退伍军人患有SFN有异常性SFN,可能与部署暴露有关.
- SFN不仅仅是GWI中自主神经系统症状的原因,需要进一步的研究来探索海湾战争暴露和SFN之间的关系.
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