神经心理症状在行为变异前性痴呆症的行为变异中随着时间的推移聚集和波动
Christopher B Morrow1, Vidyulata Kamath1, Bradford C Dickerson2
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
medRxiv : the preprint server for health sciences
|October 14, 2024
概括
神经精神症状 (NPS) 在行为变异前性痴呆症 (bvFTD) 中很常见. 这些症状分为四组:情感性,无抑制性,强迫性和精神病,提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 行为变异前性痴呆症 (bvFTD) 的特点是认知和行为变化.
- 神经精神症状 (NPS) 在bvFTD中很普遍,往往超出了核心诊断标准.
- 了解NPS集群可能会阐明bvFTD的神经生物学,并指导治疗的发展.
研究的目的:
- 在行为变异前性痴呆症 (bvFTD) 中识别和描述神经精神症状 (NPS) 集群.
- 检查bvFTD不同阶段的NPS的流行程度和稳定性.
- 探索bvFTD中NPS的潜在神经生物学基础和治疗点.
主要方法:
- 分析了来自ARTFL LEFFTDS联盟的354名零星和遗传bvFTD的参与者的数据.
- 使用CDR®加NACC FTLD得分 (早期与高级) 进行痴呆阶段的分类.
- 利用神经精神病学清单问卷和临床医生对症状的判断来捕捉精神病的状态.
- 采用多色的集群分析来定义NPS集群.
主要成果:
- 在早期和晚期bvFTD阶段,NPS的流行率很高 (≥90%).
- 四个不同的NPS集群出现了:情感,无抑制,强迫和精神病.
- 情感性 (抑郁,焦虑) 和无抑制性 (缓解) 症状在一次访问后的稳定性较低.
- 精神病和强迫症症状 (幻觉,妄想,痴迷,高口气) 显示出高稳定性.
结论:
- 在bvFTD中,NPS很常见,形成四个不同的集群.
- 这些集群可能反映了特定的神经网络的干扰,表明了干预的潜在目标.
- 一些NPS的波动性表明它们可能不是疾病进展的可靠标志物.
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