地质毒素包:开源软件,用于将时空暴露与个人和人口层面的风险联系起来
Kyle P Messier1,2, David M Reif1, Skylar W Marvel1
1Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, 27713, NC, USA.
medRxiv : the preprint server for health sciences
|October 14, 2024
概括
该GeoTox R包提供了一种新的环境风险评估方法,通过整合地理空间数据来分析复杂的压力因素混合物. 该工具有助于了解各种环境暴露对个人和人口健康的影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 地理空间分析的研究.
背景情况:
- 由于复杂的压力因素和个体多样性,环境风险表征面临着挑战.
- 整合各种压力因素 (物理,化学,社会,生态,生活方式) 是至关重要的.
- 该GeoTox框架提供了一个模块化解决方案,使用地理空间暴露数据.
研究的目的:
- 介绍一个开源的R软件包,GeoTox.
- 在风险评估的计算工作流中展示GeoTox的实用性.
- 在暴露分析中纳入个人和人口层面的多样性.
主要方法:
- 开发GeoTox开源R软件包的开发.
- 将地理空间暴露数据与毒理学框架的整合.
- 创建用于分析压力因素混合物的计算工作流程.
主要成果:
- GeoTox能够对与不良健康结果相关的分子标进行风险表征.
- 该软件包有助于对空间引用的压力因素混合物的分析.
- 已证明适用于个人和人口层面的风险评估.
结论:
- GeoTox在环境风险表征方面取得了重大进展.
- 该模块化软件支持GeoTox框架的暴露结果关系.
- GeoTox将地理空间方法与暴露和毒理学相结合,以进行可靠的风险评估.
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