胃肠道动力不良,自主功能和小肠道细菌过度生长在受良好控制的HIV感染者中
Jessica Robinson-Papp1, Mitali Mehta1, Bridget R Mueller1
1Icahn School of Medicine at Mount Sinai, Department of Neurology; New York City, NY, USA.
medRxiv : the preprint server for health sciences
|October 14, 2024
概括
艾滋病毒感染者 (PWH) 呈现出胃肠道动性的改变. 自主功能变化可能会影响小肠过渡,可能导致小肠细菌过度生长 (SIBO) 在PWH.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 胃肠道 (GI) 功能障碍,包括微生物组变化和屏障损害,有助于艾滋病毒 (PWH) 感染者的慢性炎症.
- 自主神经病变 (AN) 在改变肠道动性的作用及其对PWH中这些机制的贡献仍然不清楚.
研究的目的:
- 为了研究PWH的胃肠道运动的变化.
- 探索PWH.中自主功能,肠道过渡和小肠细菌过度生长 (SIBO) 之间的关联.
主要方法:
- 对100个PWH和89个对照进行横截面研究.
- 无线运动囊 (WMC) 用于评估胃肠道过境时间.
- 他们进行了自主功能测试 (MCASS),SIBO呼吸测试和症状问卷 (PAGI-SYM,COMPASS-31).
主要成果:
- 与对照组相比,PWH表现出更快的胃排空 (GET) 和更慢的小肠 (SBTT) 和结肠传输时间 (CTT).
- 在PWH.中,SBTT与自主运动功能 (外周交感) 有关.
- 在PWH中长时间的SBTT (>6h) 与SIBO的可能性更高有关.
结论:
- 在PWH中,胃肠道运动性发生显著变化.
- 自主功能障碍可能会影响PWH中的SBTT,可能会导致SIBO的发展.
- 需要进一步的研究来澄清与艾滋病毒相关的AN,胃肠道运动性,微生物组变化和临床结果之间的联系.
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