相关实验视频
Updated: Jun 10, 2025
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
3.4K
脂质轨迹改善了阿尔茨海默病和轻度认知障碍的风险模型
Bruce A Chase1,2, Roberta Frigerio2,3, Chad J Yucus4
1Information Technology, Endeavor Health, Skokie, IL USA.
medRxiv : the preprint server for health sciences
|October 14, 2024
概括
在认知能力下降之前,较低的HDL-C和较高的非HDL-C可变性与轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的风险增加有关. 脂质轨迹显著影响认知功能障碍的风险.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 认知功能障碍,包括轻度认知障碍 (MCI) 和阿尔茨海默病 (AD),构成了重大的公共卫生挑战.
- 了解脂质代谢在认知衰退前症状阶段的作用,对于早期干预至关重要.
研究的目的:
- 研究血脂纵向轨迹和变异性与发展稳定的MCI和AD的风险之间的关联.
- 评估脂质概况是否改善认知功能障碍风险预测模型.
主要方法:
- 追溯病例控制队列研究分析了高达十年前的认知症状之前的血脂水平.
- 参与者按胆固醇和甘油三的纵向脂质轨迹和独立于平均值 (VIM) 的可变性进行分组.
- 风险模型包括脂质组,APOE基因型,多基因风险得分 (PRS),年龄和并发症.
主要成果:
- 较低的HDL-C轨迹与MCI (OR=3.8) 和AD (OR=3.0) 的风险增加有关.
- 非HDL-C的最低VIM五分位数与更高的MCI风险相关 (OR=2.2),以及最低VIM五分位数的总胆固醇与更高的AD风险相关 (OR=2.4).
- 纳入脂质轨迹和VIM改善了超越APOE和PRS的风险预测模型.
结论:
- 血脂水平的特定模式,特别是较低的HDL-C和较高的非HDL-C/总胆固醇可变性,在MCI和AD的发展之前和相关.
- 脂质代谢在认知衰退的发病过程中起着至关重要的作用,为风险评估和预防提供了潜在的目标.
关键词:
在这里,APOEOE是APOE.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在HDL-C中使用.这就是为什么LDL,LDL是LDL.胆固醇 胆固醇 胆固醇 是一种基于组的轨迹分析.脂质 脂质 脂质 是一种多基因风险评分多基因风险评分.甘油三酸是什么?甘油三酸是什么独立于平均值的可变性.更多相关视频
10:02Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
Published on: May 28, 2017
26.6K
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
10.2K
相关概念视频
01:26Alzheimer's Disease: Overview
449
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
449
01:26Atherosclerosis III: Management
2
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
2
01:22Alzheimer's Disease: Treatment
166
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
166
01:30Dementia
97
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
97
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
135
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
135