酒精,吸烟和大脑结构:常见或特定物质的关联
Vera Thornton1, Yoonhoo Chang1, Ariya Chaloemtoem1
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
medRxiv : the preprint server for health sciences
|October 14, 2024
概括
酒精和吸烟同样会损害大脑的健康,影响大脑的结构和功能. 它们对大脑的负面影响大多是附加的,而不是互动的,影响大脑的整体健康.
科学领域:
- 神经成像是一种神经成像.
- 药物使用研究研究 药物使用研究
- 大脑健康 大脑健康
背景情况:
- 饮酒和吸烟是普遍存在的行为,与不良健康结果有关,包括认知能力下降.
- 了解这些物质的特定神经生物学影响对于公共卫生至关重要.
- 以前的研究表明了负面影响,但对它们的大脑关联的直接比较较少被探索.
研究的目的:
- 调查酒精使用和吸烟与神经成像衍生的大脑测量共享和独特的关联.
- 为了确定酒精和吸烟对大脑的综合影响是附加的还是相互作用的.
- 评估这些协会对大脑健康的指向性.
主要方法:
- 利用了来自36309名参与者的英国生物库数据,以及广泛的神经成像数据.
- 使用线性回归来分析大脑测量与酒精消费 (饮料/周) 和吸烟 (包装年) 之间的关联.
- 计算了酒精和吸烟协会z分数之间的相关性,以比较它们对大脑的影响,并测试了相互作用效应.
主要成果:
- 在大脑结构,磁性易感性和白质微观结构的测量中,在酒精和吸烟之间发现了中等的正相关性.
- 酒精和吸烟联合的主要影响是大多数大脑测量的附加,只有在皮下磁性敏感性中观察到显著的相互作用.
- 超过97%的酒精和吸烟的显著关联表明对大脑健康有不利影响.
结论:
- 酒精使用和吸烟在很大程度上与神经成像衍生的大脑测量具有相似的不良关联.
- 这些物质对大脑的有害影响主要是附加的.
- 这些发现突出了通过酒精和吸烟对大脑健康产生负面影响的共同神经生物学途径.
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