较高的甘油三糖-腰部高度比率指数与较高的胆结石患病率有关:基于人口的研究
Jianjun Wang1,2, Sirui Chen1, Xi Chen1
1Department of Hepatobiliary Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Frontiers in medicine
|October 14, 2024
概括
三糖糖-腰高度比率 (TyG-WHtR) 指数与较高的胆结石病 (GSD) 患病率有关. 增加的TyG-WHtR指数也可能与第一次胆结石手术时的年轻年龄相关.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 胆结石病 (GSD) 是一个严重的健康问题.
- 甘油三糖-腰高度比率 (TyG-WHtR) 指数是一种新的代谢功能障碍指标.
- TyG-WHtR和GSD流行率与手术时的年龄之间的关联尚未得到充分证实.
研究的目的:
- 调查TyG-WHtR指数与美国成年人胆结石病 (GSD) 患病率之间的关系.
- 检查TyG-WHtR指数与第一次胆结石手术的年龄之间的关联.
- 确定GSD的潜在风险因素和早期指标.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 采用后勤回归,通用增值建模和光滑曲线拟合.
- 进行了子组分析,以探索跨不同人口统计数据的关联.
主要成果:
- 在TyG-WHtR指数和GSD患病率之间发现了显著的正面,非线性关联.
- 泰格-WHtR的每一个单位增加与GSD流行率上升47%相关 (OR=1.47).
- TyG-WHtR指数显示,与第一次胆结石手术时的年龄存在潜在的负相关性.
结论:
- 提升的TyG-WHtR指数与增加的GSD患病率有关.
- TyG-WHtR指数可以作为胆结石疾病的早期预警标志物.
- 建议进行进一步的前性研究来验证这些发现.
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