异常的TSH水平作为COVID-19住院患者中严重结果的预测因素
Pinak A Shah1, Kartika Shetty1, Faraz Rahman1
1Mountain View Hospital, Sunrise GME, Las Vegas, NV, USA.
Journal of community hospital internal medicine perspectives
|October 14, 2024
概括
住院COVID-19患者的低甲状腺刺激激素 (TSH) 水平表明预后不佳. 这一发现表明,TSH可能是SARS-CoV-2感染严重结果的有价值指标.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 甲状腺功能障碍越来越被认为是严重感染的潜在并发症.
- 在COVID-19患者中甲状腺功能测试的预后意义仍然是积极调查的领域.
研究的目的:
- 研究COVID-19诊断的住院患者的甲状腺功能障碍和死亡率之间的关联.
- 评估甲状腺刺激激素 (TSH) 和自由甲状腺素 (fT4) 水平在预测严重的COVID-19结果中的预后价值.
主要方法:
- 一项回顾性多中心研究包括10933名因COVID-19住院的患者.
- 已经存在甲状腺疾病或治疗的患者被排除在外.
- 分析了甲状腺功能测试 (TSH,FT4) 和临床结果 (死亡率,ICU入院,通风,停留时间).
主要成果:
- 低TSH和低fT4的患者的死亡率明显更高 (OR 10.07).
- 低TSH,不论fT4水平,与增加的死亡率相关 (或1.46低TSH/正常fT4;或1.38低TSH/高fT4).
- 低TSH水平也与更高的ICU入院率和机械通风相关.
结论:
- 低TSH水平,无论fT4,都表明住院COVID-19患者的预后不佳.
- TSH水平可以作为SARS-CoV-2感染严重结果的有价值的预后标志物.
- 需要进一步的研究来阐明严重的COVID-19中甲状腺功能障碍背后的机制.
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