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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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基于脱细胞化细胞外矩阵的疾病模型用于药物查.

Zhoujiang Chen1, Ji Wang2, Ranjith Kumar Kankala3

  • 1Institute for Advanced Study, Chengdu University, Chengdu, 610106, Sichuan, PR China.

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概括

脱细胞化细胞外基质 (dECM) 生物材料为改善药物查创造了现实的疾病模型. 这些先进的dECM模型显示出对评估药物疗效和推进个性化医疗的前景.

关键词:
细胞模型 细胞模型脱细胞化 脱细胞化药物查是指对药物进行查.细胞外矩阵是细胞外矩阵.个性化医疗是个性化的医疗.

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科学领域:

  • 生物材料科学 生物材料科学
  • 药物发现 药物发现 药物发现
  • 再生医学是一种再生医学.

背景情况:

  • *体外药物查旨在模仿体内细胞环境,以准确预测药物反应.
  • * 脱细胞化外细胞矩阵 (dECM) 提供了一个生物学相关的支架,用于疾病建模的体内条件.
  • * ECM组件对于细胞功能和疾病进展至关重要,使dECM成为疾病模型的理想选择.

研究的目的:

  • * 审查使用基于dECM的生物材料来创建用于药物查的细胞模型的进展.
  • * 探索dECM在各种疾病的疾病建模中的潜力.
  • * 总结dECM在药物评估和个性化医学中的挑战和未来方向.

主要方法:

  • * ECM组件功能和它们在疾病模型中的作用的划定.
  • * 脱细胞化技术的阐明和dECM基板制造用于细胞模型.
  • *对使用dECM模型进行各种疾病 (癌症,心脏,肝脏,肺部,骨) 药物查的研究进行审查.

主要成果:

  • * 与传统方法相比,基于dECM的材料提供了更真实的细胞环境.
  • * dECM模型已经证明在针对各种病理的药物查中具有实用性.
  • *确定了dECM在药物查和个性化医学中的瓶和未来研究途径.

结论:

  • * dECM生物材料在为药物查创建生理上相关的细胞模型方面取得了重大进展.
  • * dECM模型的应用在增强药物发现和实现个性化治疗方面具有重大前景.
  • * 对dECM制造和应用的持续研究将加速其融入临床药物评估.