在细胞癌中,与铁生相关的基因和化合物
Chengwu He1, Qingyi Li1, Weijia Wu1
1Department of Urology, Shenzhen Shockwave Lithotripsy Research Institute, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Frontiers in immunology
|October 14, 2024
概括
清细胞细胞癌 (ccRCC) 涉及VHL基因变异,影响新陈代谢和细胞死亡途径,如铁亡. 了解铁酶相互作用是开发用于ccRCC治疗新组合药物策略的关键.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症新陈代谢 癌症新陈代谢
背景情况:
- 清细胞细胞癌 (ccRCC) 是癌最常见的亚型.
- 在ccRCC中VHL基因突变导致代谢重编程和改变细胞死亡途径,包括铁亡.
- 铁,一种调节的细胞死亡形式,涉及铁,与ccRCC的发展和对治疗的反应有关.
研究的目的:
- 在ccRCC中总结关键的基因和与ferroptosis相关的化合物.
- 探索铁化在ccRCC治疗策略中的作用,包括向治疗和免疫治疗.
- 通过基于铁灭的方法,提供了解克服ccRCC耐药性的方法.
主要方法:
- 关于铁亡,VHL变化和ccRCC的研究的文献综述.
- 对代谢变化,细胞死亡途径和瘤微环境相互作用的分析.
- 在ccRCC中检查与ferroptosis相关的分子,基因和化合物.
主要成果:
- 在ccRCC中的VHL变化激活缺氧诱导因素,促进代谢变化和铁亡.
- 铁酶调节剂 (例如,谷氨酸过氧化酶4,谷胺酶) 影响ccRCC细胞活力和反应性氧物种水平.
- 铁生可以与向治疗,免疫治疗和放射治疗协同作用,但也可能促进瘤生长.
结论:
- 铁化是ccRCC的一个有前途的治疗策略,涉及铁和脂质代谢.
- 进一步了解瘤微环境中的铁灭相互作用对于开发新型组合疗法至关重要.
- 向铁亡途径可能为克服ccRCC治疗耐药性的新途径提供了新的途径.
相关概念视频
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:12Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K