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饮食模式,遗传倾向和胆病风险:一个大规模的前性队列研究
Kecheng Jin1,2, Ningning Mi1,2, Wangping He1,2
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Frontiers in nutrition
|October 14, 2024
概括
坚持地中海饮食评分 (aMED) 和2015年健康饮食指数 (HEI-2015) 的选择可以显著降低胆病风险. 这些健康的饮食模式提供了预防胆结石的潜力,无论遗传倾向如何.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 遗传学 是一个遗传学.
背景情况:
- 有限的流行病学数据存在于健康饮食对胆病 (胆) 风险的影响.
- 调查饮食模式与胆结石形成之间的关联对于公共卫生至关重要.
研究的目的:
- 为了检查七种饮食模式与胆病风险的关联.
- 为了确定遗传倾向是否改变饮食对胆结石风险的影响.
主要方法:
- 对155,323名英国生物库参与者的前性队列研究.
- 通过牛津WebQ食物频率调查问卷评估的饮食模式.
- 使用多基因风险评分 (PRS) 评估遗传风险;用于分析的Cox比例危险回归.
主要成果:
- 按照aMED和HEI-2015的标准,胆病风险分别降低了10%和11%.
- 较低的遗传风险 (PRS) 与胆结石风险降低16%有关.
- 结合对aMED/HEI-2015的高度坚持和低遗传风险,显示出胆病发病率最低.
结论:
- 像aMED和HEI-2015这样的健康饮食模式可能会显著降低胆病风险.
- 饮食干预措施对一般人群的胆结石预防有希望.
- 这些饮食的保护作用似乎独立于遗传风险因素.
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