溶性转移林受体与婴儿心脏手术中的红细胞输血有关
1Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Translational pediatrics
|October 14, 2024
概括
高的手术前可溶性转激素受体 (sTfR) 水平预测了接受心脏手术的婴儿需要输血红细胞 (RBC). 这一发现有助于管理儿科心脏病患者的输血需求.
科学领域:
- 儿科心脏手术 儿科心脏手术
- 血液学 血液学 血液学
- 输血医学 输血医学
背景情况:
- 缺铁 (ID) 增加了红细胞 (RBC) 输血需要在心脏手术.
- 传统的ID标记物对炎症敏感;可溶性转激素受体 (sTfR) 受影响较小.
- 在炎症性外科背景下,sTfR可能提供更可靠的ID评估.
研究的目的:
- 调查手术前可溶性转移素受体 (sTfR) 水平与大量红细胞输血需求之间的关联.
- 评估sTfR作为儿童心脏外科手术中红细胞输血的预测标记.
主要方法:
- 该研究包括236名体重较低的婴儿 (≤10公斤) 接受心脏手术 (2021年8月至2022年7月).
- 记录了手术前的sTfR水平和手术后的红细胞输血量.
- 采用了接收器操作特征 (ROC) 曲线分析和多变量逻辑回归.
主要成果:
- 29名 (12.3%) 患者在术前接受了>2单位红血细胞.
- sTfR水平在预测红细胞输血需求方面表现出最高的准确性 (AUC = 0.643).
- 术前升高的sTfR水平与红细胞输血量增加显著相关 (P=0.006;P<0.001).
结论:
- 红细胞 (RBC) 输血经常发生在接受心脏手术的体重较低的婴儿中.
- 在这个人群中,高的手术前sTfR水平是对实质性的手术前红细胞输血需求的重要预测指标.
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