从患者分类到ART的优化治疗:AMPLITUDE Delphi共识共识
Christophe Blockeel1, Anne Guivarc'h-Leveque2, Catherine Rongieres3
1Brussels IVF, Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Frontiers in reproductive health
|October 14, 2024
概括
专家们就辅助生殖技术的个性化卵巢刺激方案达成共识. 关键因素包括初始性腺激素剂量,新鲜或冷胚胎移植策略,以及最佳的卵细胞产量,以改善患者的治疗结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 卵巢刺激方案需要优化,以便在ART中提供个性化的患者护理.
- 专家意见在管理卵巢刺激的关键方面有所不同,需要达成共识.
研究的目的:
- 在生育专家之间建立关于优化卵巢刺激协议的德尔菲共识.
- 根据预测的卵巢反应,为患者个人资料制定基于证据的建议.
主要方法:
- 一个科学委员会为患者个人资料 (低响应,正常响应,高响应) 开发了11个陈述.
- 法国和比利时的生育专家使用在线平台进行了调查.
- 共识被定义为≥66.7%的参与者同意的共识.
主要成果:
- 在考虑患者特定因素的情况下,就个性化初始淋巴激素剂量达成共识.
- 优先考虑的新转移 (低/正常响应者) 与结所有策略 (高响应者/特定条件) 相比.
- 商定了10-15个最佳卵细胞目标,并制定了调整淋巴激素剂量和选择后续周期协议的策略.
结论:
- AMPLITUDE的共识强调了在ART中量身定制的卵巢刺激方案的重要性.
- 这些发现为生育专家提供了指导,以提高卵巢刺激结果.
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