[COVID-19大流行对精液质量的影响]
Patricia Chenlo1,2, Julia Ariagno1,2, Florencia Mauro1
1Laboratorio de Fertilidad Masculina, Hospital de Clínicas José de San Martín, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Medicina
|October 14, 2024
概括
由于COVID-19的流行,男性的精子数量暂时减少,这可能是由于发烧和炎症,而不是病毒本身. 精子变量随着时间的推移而恢复,表明对男性生育能力的可逆影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 丸中SARS-CoV-2受体的存在表明可能对男性生殖健康产生影响.
- 随着COVID-19的流行,人们不得不进行社会隔离,并导致广泛的疫苗接种,促使对其影响进行调查.
研究的目的:
- 为了评估COVID-19大流行对男性种子变量的影响.
- 评估COVID-19感染,社会隔离和疫苗接种对精子参数的影响.
主要方法:
- 一项观察性研究分析了来自409个样本的精液分析和动力学值.
- 计算机辅助精子分析用于大流行前 (2019年) 和大流行期间 (2021年) 收集的样本.
- 根据患病以来的时间,COVID-19阳性患者被分层:急性 (<3个月),4-12个月和>1年.
主要成果:
- 与大流行前和COVID负组相比,在COVID-19阳性个体中观察到每次射精的精子总数显著减少 (p=0.013).
- 这种减少在急性阶段 (感染后<3个月) (p=0.038) 显著.
- 种子变量随着时间的推移出现恢复,恢复到与对照组相似的水平;社会隔离和疫苗接种没有显著影响种子参数.
结论:
- COVID-19 感染可能导致丸功能发生可逆变化,导致精子数量减少.
- 与COVID-19相关的发烧和炎症似乎是这些重大变化的主要驱动因素,而不是直接的病毒感染.
- 这些发现表明,在COVID-19感染后,男性生育能力会受到暂时的影响,随着时间的推移而恢复.
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