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Updated: Jun 10, 2025

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与mtDNA突变相关的线粒体功能障碍:在动脉样硬化研究中进行线粒体基因组编辑

Victoria A Khotina1, Andrey Y Vinokurov2, Vasily V Sinyov3,4,5

  • 1Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315Moscow, Russia.

Current medicinal chemistry
|October 14, 2024
PubMed
概括

线粒体DNA (mtDNA) 中的m.15059G>A突变驱动了与动脉样硬化有关的线粒体功能障碍. 消除这种突变恢复了线粒体膜的潜力,并改善了细胞生物能,突出了其致病作用.

关键词:
动脉样硬化是一种动脉样硬化.线粒体DNA突变的突变潜在的线粒体膜潜力线粒体呼吸系统的呼吸过程有活性氧物种.

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