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探索COVID-19对精神分裂症口头记忆功能的影响:多个案例研究和简短的文献综述
Barbora Keřková1, Marián Kolenič1,2, Karolína Knížková1,3
1National Institute of Mental Health, Klecany, Czech Republic.
Applied neuropsychology. Adult
|October 14, 2024
概括
在精神分裂症患者中,COVID-19并没有持续影响口头记忆. 像BMI和血压这样的因素可能会影响这些人的COVID-19和认知功能之间的关系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 持续的口头记忆障碍在COVID-19后很常见,可能与海马损伤有关.
- 语言记忆缺陷是精神分裂症的核心特征,但其与COVID-19的相互作用尚未研究.
- 之前没有任何神经成像研究研究过精神分裂症和COVID-19对口头记忆的联合影响.
研究的目的:
- 探索COVID-19对精神分裂症患者口头记忆的影响.
- 关于可能缓解COVID-19与精神分裂症认知功能之间的关系的因素,提出假设.
- 对于有或没有COVID-19病史的精神分裂症患者,研究海马体积的变化.
主要方法:
- 多个案例研究设计比较两对精神分裂症患者 (COVID-19阳性和阴性).
- 使用可靠变化指数评估口头记忆性能.
- 计算了海马体体积的年均变化率,并与规范数据进行了比较.
主要成果:
- COVID-19阳性病例显示有不一致的口头记忆变化;一个下降,另一个正常化.
- 左海马体积呈现缓慢增长,而右海马体显示下降.
- 观察到的海马体积变化没有超过一般人群的比率.
结论:
- 仅仅是COVID-19可能不会导致精神分裂症的口头记忆力下降.
- COVID-19和精神分裂症之间的相互作用可能受到其他因素的影响,例如BMI,血压,性别,疾病阶段和灰质体积.
- 需要进一步的研究来确定COVID-19后精神分裂症患者认知结果的预测因子和调节因子.
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