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在临床前的关节炎模型中,IDO2通过抑制B细胞中的Runx1功能来驱动自身抗体的产生和关节炎症

Weidan Peng1, Lauren M F Merlo1, Samantha Grabler1

  • 1Lankenau Institute for Medical Research, Wynnewood, PA.

Journal of immunology (Baltimore, Md. : 1950)
|October 14, 2024
PubMed
概括

印度醇胺2,3-二氧化酶2 (IDO2) 通过抑制B细胞中的Runx1功能来驱动自身免疫性关节炎. 针对IDO2-Runx1相互作用,为自身免疫性疾病提供了一种新的治疗策略.

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