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Updated: Jun 10, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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卡里奥兰-1-合成酶的晶体结构,一种基合成酶催化初始的反马尔科夫尼科夫循环反应

Ramasamy P Kumar1, Jason O Matos1, Brandon Y Black1

  • 1Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.

Biochemistry
|October 14, 2024
PubMed
概括

对合成酶机制的结构洞察力揭示了关键活性位点残留物,如W56和F183,如何指导基质循环. 这些残留物中的突变会破坏反应,产生非循环产物而不是循环烯.

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