基于指纹和网络药理学的Astragali Complanati精液的Q标记预测
Xiaozhou Jia1,2, Weisheng Lv1, Cuijie Wei1
1Guangdong Yifang Pharmaceutical Co. Ltd, Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Formula, Guangdong, Foshan 528244, China.
Journal of AOAC International
|October 14, 2024
概括
这项研究建立了一种可靠的UPLC方法来控制Astragali Complanati精液 (ACS) 的质量. 网络药理学确定了12个潜在的ACS质量标志物 (Q标志物),确保其药物疗效.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- 阿斯特拉加利复合精液 (Astragali Complanati Semen,简称ACS),也称为夏子 (Shayuanzi),是一种传统的中医药,用于治疗脏和相关疾病.
- 它的治疗性质需要强有力的质量控制措施.
研究的目的:
- 为了为ACS.建立超高性能液态染色学 (UPLC) 指纹.
- 通过网络药理学识别ACS的潜在质量标志物 (Q-标志物).
主要方法:
- 开发并验证了一种用于ACS指纹的UPLC方法.
- 使用UPLC-MS/MS.识别的常见峰值.
- 使用网络药理学构建了一个组件-目标-通路网络来预测Q标记物.
主要成果:
- 为ACS建立了一个UPLC指纹,其中有24个常见的峰值.
- 通过UPLC-MS/MS.确定了12个染色学峰值.
- 通过网络药理学分析,选了12种候选Q标记物,包括特定的糖化物和黄类,通过网络药理学分析.
结论:
- 开发的UPLC方法对于ACS质量检测是准确的,可靠的,简单的和实用的.
- 已确定的12个Q标记器为ACS质量控制和保证提供了科学基础.
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