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Updated: Jun 10, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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通过基突变和脂质进行TRPML1门调节

Ninghai Gan1,2, Yan Han2, Weizhong Zeng1,2

  • 1Howard Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.

eLife
|October 14, 2024
PubMed
概括

研究人员在TRPML1通道中发现了关键残留物Tyr404,该残留物对于调节IV型粘脂症中其功能至关重要. 这个部位的突变为开发TRPML1激活剂和抑制剂创造了新的标.

关键词:
TRPML TRPML 在线播放暂时的受体潜在的粘脂蛋白.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.离子通道 离子通道 离子通道分子生物物理学分子生物物理学这里是鼠标鼠标鼠标鼠标鼠标鼠标.结构生物学结构生物学

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