系统性免疫炎症指数与全因和因特定死亡率:一个元分析
Wei Li1, Xiaoning Wang2, Houze Diao1
1Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
概括
系统性免疫炎症指数 (SII) 与所有原因和心血管疾病死亡率的风险更高有关. 需要进一步的研究来证实这些关联.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于系统性免疫炎症指数 (SII) 与死亡率之间的关联存在不一致的发现.
- 了解这种关系对于公共卫生和临床实践至关重要.
研究的目的:
- 调查SII与所有原因死亡风险之间的关联.
- 探索SII与特定原因死亡率 (包括心血管疾病和癌症) 之间的联系.
主要方法:
- 进行了全面的元分析,包括到2024年3月1日的PubMed,Embase,Cochrane和Web of Science的文献搜索.
- 进行了子组分析和剂量反应评估,以完善对死亡风险因素的理解.
- 该分析包括了33篇文章,包括427,819名参与者.
主要成果:
- 分析发现,较高的SII与所有原因死亡风险的增加显著相关 (HR=1.45,95%CI [1.36,1.54]).
- 此外,SII还与心血管疾病死亡率更高的风险有关 (HR=1.44,95% CI [1.29,1.60]).
- 在SII的100个单位增加与所有原因死亡风险的5%增加和心血管疾病死亡风险的6%增加相关. 没有发现与癌症死亡率有显著的关联.
结论:
- 系统性免疫炎症指数 (SII) 与全因和心血管疾病死亡率的增加有关.
- 需要进一步的基础研究和数据来验证这些发现并阐明潜在的机制.
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